Find patient medical information for Tizanidine (Zanaflex) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Zanaflex (tizanidine) is a short-acting muscle relaxer used to treat spasticity by temporarily relaxing muscle tone. Includes Zanaflex side effects, interactions and indications. Tizanidine is a short-acting muscle relaxant and is used to treat spasticity. Learn about side effects, interactions and indications. Learn about Zanaflex: What is it used for, what you need to know before taking, important warnings and safety info, how to take, side effects and more… Learn which drugs, foods, and habits are unsafe to combine with tizanidine (Zanaflex), including absolute contraindications and hidden risks. Tizanidine (Zanaflex) is a muscle relaxer that's FDA approved to treat muscle spasticity. If you're prescribed tizanidine, knowing about possible tizanidine warnings, including drug interactions, can help keep you safe. 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